Premier League leaders Arsenal will host north London rivals Tottenham Hotspur in the standout tie of the FA Cup third round following the draw on Sunday.
Struggling Manchester United, the 11-times Cup winners, will be at home to fellow Premier League side Swansea City, Chelsea go to Championship side Derby County and Manchester City, beaten finalists last season, visit Blackburn Rovers, another Championship team.
Wigan Athletic, who surprisingly beat City in the final in May before being relegated from the top flight, begin their defence against third tier MK Dons.
There will be three other all Premier League ties in the third round, played in the first week of January, as teams from the Premier League and Championship (second tier) enter the competition.
Norwich City host Fulham, Newcastle United play Cardiff City and West Bromwich Albion meet Crystal Palace.
Liverpool could face League One (third tier) Oldham Athletic, who stunned them in last year’s competition, providing Oldham overcome Mansfield Town of League Two.
None of the three minor league clubs definitely through to the third round were handed glamour ties, leaving the north London derby as the main talking point.
“There are not enough tough games, they gave us another one,” Arsenal manager Arsene Wenger told reporters following his side’s 1-1 Premier League draw with Everton who will face Championship high-flyers Queens Park Rangers.
Arsenal and Tottenham have not met in the world’s oldest domestic cup competition since the Gunners beat Spurs in the 2001 semi-final
FA Cup third-round draw
Barnsley v Hartlepool or Coventry
Yeovil v Leyton Orient
Liverpool v Oldham or Mansfield
Nottingham Forest v West Ham
Bristol City v Watford
Southend v Millwall
Middlesbrough v Hull
West Brom v Crystal Palace
Kidderminster v Peterborough
Doncaster v Stevenage
Stoke v Leicester
Southampton v Burnley
Newcastle v Cardiff
Rochdale v Leeds
Wigan v MK Dons
Charlton v Wrexham or Oxford United
Manchester United v Swansea
Port Vale v Plymouth
Norwich City v Fulham
Aston Villa v Sheffield United
Macclesfield v Sheffield Wednesday
Sunderland v Carlisle
Bolton v Blackpool
Blackburn v Manchester City
Everton v QPR
Brighton v Reading
Arsenal v Tottenham
Birmingham v Bristol Rovers or Crawley
Grimsby v Huddersfield
Ipswich v Preston
Derby v Chelsea
Bournemouth v Fleetwood or Burton
Ties to be played over the weekend of 4-5 January