Detectives are appealing for witnesses and information following the assault close to Oxford Street.
Police were called at 17:38hrs on Saturday, 8 August to reports of an assault on Market Place at the junction with Oxford Street, W1.
Officers attended and found a male, aged in his late teens, suffering from a stab injury.
He was taken by the London Ambulance Service to a central London hospital where he was pronounced dead at 19:33hrs.
His next of kin has been informed. Formal identification awaits.
A post-mortem examination will be held in due course.
Homicide detectives from the Specialist Crime Command are investigating.
Three males [no further details] have been arrested in connection with the investigation.
Enquiries continue.
Anyone with information is asked to call police via 101 quoting reference Cad 6404/08Aug.